Written by Jessica Patella, ND. Of the fifty-seven children with Autism Spectrum Disorder, those who received an intramuscular injection of vitamin B 12 every three days for eight weeks showed a significantly greater improvement in B 12 methylation than the placebo group.
According to the CDC the autism rates are now one in every sixty-eight children 1. One challenge that tends to occur in autistic children is difficulty with metabolic processes, specifically methylation and oxidative stress 2,3. Vitamin B 12 is a key element in methylation and has been shown to improve oxidative stress 2,4. Recent research has found treatment with vitamin B 12 in the methyl form, improved symptoms in autistic children 2. The most studied and proven treatment is Speech and Language therapy, in some combination with other important traditional treatments, such as ABA or OT.
Astounding recovery may take place, depending on how early a problem is recognized and addressed. What happens when these modalities are not effective? More therapy? The use of vitamin methylB12 injections has shown safety, tolerance, and improvement in a subgroup of individuals in a study.
At a recent MedMaps. Be patient. Be realistic about the next developmental step. If the child already speaks, look for more words that require less prompting and new words to appear intermittently. The next step is speaking to toys and family members, and socialization may then generalize.
Continue or even increase the Speech therapy. Achieving optimal health and the ability to learn must be complemented with proper instruction. Suspect on-going inflammation. Yeast, bad bacteria, and food intolerance could be using up much of the energy that it takes for the correct areas of the brain to wake up. The suggested dosage is Many practitioners will increase the dose and frequency if there is little response.
Check for a problem in the pathway leading to glutathione production. A genetic mutation in the step that makes folinic acid MTHFR , or too much tylenol blocking the normal formation, may be interfering with mB12 treatment.
Other medications that the child is prescribed, such as stimulants and anti-anxiety preparations, may be impeding progress and interfering with recovery. Parents are often confused about the various formulations of the vitamin; including sublingual, patch, pill, and lollipops.
It is water soluble, leaves the body easily, and needs to be administered in a form that slowly leaks into the circulation. The successful substance is injected subcutaneously — under the skin and into the fat. The preparation should be ordered from a reputable pharmacy that is familiar with the product. Simply changing the compounding dispensary may improve results. I recently tried taking Vitamin B12 first thing in the morning at around 6am and found it helps clear my head of the brain fog and depression that my Autism causes me.
It also helps to clear my sinuses and helps to improve my breathing. Strangely, it only seems to work if I take it early in the morning. If I take it any later it makes me feel tired and groggy. I have a 3 year old daughter with regressive autism. Have been doing methyl b12 shots. Do you like adding folinic acid in with the methyl b12? Or does methyl b12 work better by itself? Thank you so much. There are many reasons why one supplement works for one child but not another.
The two top reasons are 1. The gastrointestinal system needs addressing and 2. A practitioner who ascribes to the work at www. My 12 year old son with autism is nonverbal. He has severe speech apraxia.
We tried B6, magnesium and DMG around the age of and he made huge progress in attention receptive language. His pediatrician just told us about a combination of B12, mag, and folate. He is also really rigid about routine and OCD tendencies.
Thanks for your input. It could be helpful… starting with low dosing and close observation, and hold off if behaviors become too amplified. Your email address will not be published. Make An Appointment. Here are the top questions and answers about vitamin B12 that I encounter in the practice: Does it work? That is, the child will not only improve in words, then articulation, but many parents report that their children notice things that were previously ignored, respond to questions with more understanding and even begin to ask questions spontaneously.
The scientific literature is presently woefully short of research in this area. Probably, the best research so far is a rigorous 12 week clinical trial on 30 ASD patients aged 3 to 8 years. In my practice, I have found that there are clinical symptoms that can help identify those responders.
How does it work? A couple of studies were able to demonstrate some autism patients who had decreased intake of the vitamin in their restricted diets 1 , 2. Therefore, those patients benefitted from the supplementation of the vitamin B The prevailing theory on why Vitamin B12 may be effective in many neuromuscular and other conditions is that the METHYL methylcobalamin group acts to aid in detoxification and to improve cellular energy. How is it administered? Vitamin B12 is water soluble vitamin and so there are many available forms — oral, gel, nasal, sublingual, and even in lollipop form.
In practice, however, I have only found a biologic effect when it is given subcutaneously. This clinical observation is possibly because the methylcobalamin delivered by this method is better absorbed into the bloodstream, or it is more bio-available, or the effect is more noticeable because of the constantly higher blood level.
No good word has come out yet on the B12 patch. The best dietary sources are from animal products such as meat, fish, eggs and dairy which causes inflammation in many of our patients. As a side note, no plant foods can be relied on as a sole source of vitamin B We usually start a patient with a twice-a-week dosage regimen. This negates the need for additives such as lidocaine or expensive protocols that include EMLA cream to numb the skin.
Done in this manner, it is quick and painless for the child and the parent. The dosage is pretty much standard for each child, though depending on the clinical response, we may change the frequency of the injections to maximize improvement or minimize annoying effects below.
The product is delivered periodically through a compounding pharmacy. How long does it take to see an improvement from the Vitamin B12 protocol? More importantly, from our interviews and observations, we try to tell the parents exactly WHAT to look for in EACH child — since they are all so different and individual effects can vary.
The therapy can be discontinued at any time without harm to the patient. What are the side effects of B12 injections? I always tell my patients that the main side effect of increased energy is increased energy. It is for this reason that: The patient needs to have yeast and intestinal flora under control first and Aggressive and other disruptive behaviors may become more pronounced when therapy is begun.
Liver, kidney and allergic reactions have been reported with other forms NOT methylcobalamin of B Because of the low toxicity of vitamin B12, no tolerable upper intake level was set by the Food and Nutrition Board in when the RDA was revised.
There is a certain type of anemia associated with too much B12, and so clearly, a physician should be ordering the medication, and should follow the patient closely for any problems. Some antibiotics may not be absorbed as well when taking B12 externally. How much will it cost? How long will the child need to get the subcutaneous injections? On the average, our patients seem to get the best benefits in the first 6 — 9 months of treatment. Some individuals have taken this therapy for years, however.
Yoshinori on October 1, at am. Udell on October 2, at pm. Yoshinori on October 2, at pm. I try to find. Brian Udell on July 17, at pm. Elena on July 17, at am. Veronica on December 12, at pm. How common, and why, are serum B levels high in those with autism? Udell on December 13, at pm. Udell on March 18, at pm. Wj on May 8, at pm. Thanks Reply. Kimberly on April 11, at pm. Thank You Reply. Udell on April 11, at pm. Chris on November 2, at pm. Brian Udell on November 2, at pm.
Udell on April 18, at pm. Udell on May 22, at pm. Nicole on August 7, at pm. Udell on August 9, at am. Answered privately Reply. Feel free to visit my web page get rid of mice Reply. I am slowly starting to get worried. Has this treatment work for other parents too? Udell on August 25, at am. Udell on September 22, at pm. A pediatrician trained in autism to examine and follow the patient, just like in any other medical condition Reply. Gudrun on January 9, at am. Misrak on January 23, at am.
Udell on January 23, at am. Hi I have a son that is 14 now and at 7 he had no speech at all he start receive b12 shot and now I see a mass improvement in speech so I say b12 shot does work Reply. Udell on May 6, at am. Udell on June 9, at pm.
This has been a really wonderful article. Thanks for providing this info. Tamara on July 21, at am. Udell on July 21, at pm. Madge on July 22, at pm. Udell on July 23, at am. Udell on August 3, at pm. Some may inquire about the flavoring ingredient —? Chavie Chazan on November 3, at am. Dear Dr. Yudell, I have a granddaughter aged three and a half years old who hardly talks.
Thank you so much Reply. Udell on November 3, at am.
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